I would not drive a car without confirming all the air is out of the system. By removing the hose, you are allowing air to travel up the system, all it takes is a bend to cause an air lock. for the sake of pressing the brake pedal a couple of times, its not worth risking.
When you remove the flexi as it's clamped air will enter the flexi a small amount & when you fit the caliper ir is inside the caliper.
By opening the bleed nipple if you sit there and watch you will start to see bubbles coming eventually if your hearing is spot on you just might hear the air coming out, eventually the fluid starts dripping out nip it up job done.
Unless you have had various pipes off and replaced other calipers then i would do a full bleed but not for just the one caliper. But it's up to you.
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